Targeting Resistance Pathways in Cancer
What We Do
MET inhibitors have recently been approved, yet they all suffer from the same issue: resistance is quick to arise.
The RAS pathway is located downstream of MET, RAS pathway inhibitors represent a promising new target for overcoming or delaying these resistance issues.
DeuterOncology’s lead compound DO-2 is a dual MET and RAS pathway inhibitor under pre-clinical investigation as a targeted therapy for lung cancer, as well as potential broader oncology applications when used in combination with other SOC and targeted agents.
DeuterOncology has also licensed DO-1, a clinical stage highly selective MET kinase inhibitor that has a recommended Phase 2 dose identified.
DeuterOncology’s portfolio contains a sublicense to the all OCTIMET compounds, includes a clinical-stage MET kinase inhibitor that has been evaluated in both a monotherapy and combination therapy setting in cancer patients in Europe. DeuterOncology works together with a broad established network of collaborators across the world to try to bring new solutions to cancer patients.